13C and 15N natural isotope abundance reflects breast cancer cell metabolism
Identifieur interne : 002502 ( Main/Exploration ); précédent : 002501; suivant : 00250313C and 15N natural isotope abundance reflects breast cancer cell metabolism
Auteurs : Illa Tea [France, Australie] ; Estelle Martineau [France] ; Ingrid Antheaume [France] ; Julie Lalande [France] ; Caroline Mauve [France] ; Francoise Gilard [France] ; Sophie Barillé-Nion [France] ; Anneke C. Blackburn [Australie] ; Guillaume Tcherkez [Australie]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Breast cancer is the most common cancer in women worldwide. Despite the information provided by anatomopathological assessment and molecular markers (such as receptor expression ER, PR, HER2), breast cancer therapies and prognostics depend on the metabolic properties of tumor cells. However, metabolomics have not provided a robust and congruent biomarker yet, likely because individual metabolite contents are insufficient to encapsulate all of the alterations in metabolic fluxes. Here, we took advantage of natural 13C and 15N isotope abundance to show there are isotopic differences between healthy and cancer biopsy tissues or between healthy and malignant cultured cell lines. Isotope mass balance further suggests that these differences are mostly related to lipid metabolism, anaplerosis and urea cycle, three pathways known to be impacted in malignant cells. Our results demonstrate that the isotope signature is a good descriptor of metabolism since it integrates modifications in C partitioning and N excretion altogether. Our present study is thus a starting point to possible clinical applications such as patient screening and biopsy characterization in every cancer that is associated with metabolic changes.
Url:
DOI: 10.1038/srep34251
PubMed: 27678172
PubMed Central: 5039687
Affiliations:
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xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Cancer Metabolism and Genetics Group, The John Curtin School of Medical Research, The Australian National University</institution>, Canberra 2601 ACT,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martineau, Estelle" sort="Martineau, Estelle" uniqKey="Martineau E" first="Estelle" last="Martineau">Estelle Martineau</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>EBSI team, CEISAM, University of Nantes-CNRS UMR 6230</institution>, 2 rue de la Houssinière BP 92208, F-44322 Nantes,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Spectromaitrise, CAPACITÉS SAS, 26 Bd Vincent Gâche</institution>, 44200 Nantes,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antheaume, Ingrid" sort="Antheaume, Ingrid" uniqKey="Antheaume I" first="Ingrid" last="Antheaume">Ingrid Antheaume</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>EBSI team, CEISAM, University of Nantes-CNRS UMR 6230</institution>, 2 rue de la Houssinière BP 92208, F-44322 Nantes,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lalande, Julie" sort="Lalande, Julie" uniqKey="Lalande J" first="Julie" last="Lalande">Julie Lalande</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>EBSI team, CEISAM, University of Nantes-CNRS UMR 6230</institution>, 2 rue de la Houssinière BP 92208, F-44322 Nantes,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mauve, Caroline" sort="Mauve, Caroline" uniqKey="Mauve C" first="Caroline" last="Mauve">Caroline Mauve</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Plateforme Métabolisme-Métabolome, Bâtiment 630 IPS2, Université Paris-Sud</institution>, 91405 Orsay cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gilard, Francoise" sort="Gilard, Francoise" uniqKey="Gilard F" first="Francoise" last="Gilard">Francoise Gilard</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Plateforme Métabolisme-Métabolome, Bâtiment 630 IPS2, Université Paris-Sud</institution>, 91405 Orsay cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barille Nion, Sophie" sort="Barille Nion, Sophie" uniqKey="Barille Nion S" first="Sophie" last="Barillé-Nion">Sophie Barillé-Nion</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>CRCNA, UMR INSERM U892/CNRS 6299/Université de Nantes, Team 8 «Cell survival and tumor escape in breast cancers», Institut de Recherche en Santé de l’Université de Nantes</institution>, 8 quai Moncousu, BP 70721, 44 007 Nantes cedex 1,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blackburn, Anneke C" sort="Blackburn, Anneke C" uniqKey="Blackburn A" first="Anneke C." last="Blackburn">Anneke C. Blackburn</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Cancer Metabolism and Genetics Group, The John Curtin School of Medical Research, The Australian National University</institution>, Canberra 2601 ACT,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tcherkez, Guillaume" sort="Tcherkez, Guillaume" uniqKey="Tcherkez G" first="Guillaume" last="Tcherkez">Guillaume Tcherkez</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Research School of Biology, The Australian National University</institution>, Canberra 2601 ACT,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Breast cancer is the most common cancer in women worldwide. Despite the information provided by anatomopathological assessment and molecular markers (such as receptor expression ER, PR, HER2), breast cancer therapies and prognostics depend on the metabolic properties of tumor cells. However, metabolomics have not provided a robust and congruent biomarker yet, likely because individual metabolite contents are insufficient to encapsulate all of the alterations in metabolic fluxes. Here, we took advantage of natural <sup>13</sup>C and <sup>15</sup>N isotope abundance to show there are isotopic differences between healthy and cancer biopsy tissues or between healthy and malignant cultured cell lines. Isotope mass balance further suggests that these differences are mostly related to lipid metabolism, anaplerosis and urea cycle, three pathways known to be impacted in malignant cells. Our results demonstrate that the isotope signature is a good descriptor of metabolism since it integrates modifications in C partitioning and N excretion altogether. Our present study is thus a starting point to possible clinical applications such as patient screening and biopsy characterization in every cancer that is associated with metabolic changes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Graham, D Y" uniqKey="Graham D">D. Y. Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, H L" uniqKey="Schmidt H">H.-L. Schmidt</name></author><author><name sortKey="Robins, R J" uniqKey="Robins R">R. J. Robins</name></author><author><name sortKey="Werner, R A" uniqKey="Werner R">R. A. Werner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartstow, T J" uniqKey="Bartstow T">T. J. Bartstow</name></author><author><name sortKey="Cooper, D M" uniqKey="Cooper D">D. M. Cooper</name></author><author><name sortKey="Epstein, S" uniqKey="Epstein S">S. 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Hodges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bathellier, C" uniqKey="Bathellier C">C. Bathellier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bah, N" uniqKey="Bah N">N. Bah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saeed, A I" uniqKey="Saeed A">A. I. Saeed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melzer, E" uniqKey="Melzer E">E. Melzer</name></author><author><name sortKey="Schmidt, H L" uniqKey="Schmidt H">H. L. Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, A" uniqKey="Gilbert A">A. Gilbert</name></author><author><name sortKey="Silvestre, V" uniqKey="Silvestre V">V. Silvestre</name></author><author><name sortKey="Robins, R J" uniqKey="Robins R">R. J. Robins</name></author><author><name sortKey="Remaud, G S" uniqKey="Remaud G">G. S. Remaud</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Tea, Illa" sort="Tea, Illa" uniqKey="Tea I" first="Illa" last="Tea">Illa Tea</name></noRegion><name sortKey="Antheaume, Ingrid" sort="Antheaume, Ingrid" uniqKey="Antheaume I" first="Ingrid" last="Antheaume">Ingrid Antheaume</name><name sortKey="Barille Nion, Sophie" sort="Barille Nion, Sophie" uniqKey="Barille Nion S" first="Sophie" last="Barillé-Nion">Sophie Barillé-Nion</name><name sortKey="Gilard, Francoise" sort="Gilard, Francoise" uniqKey="Gilard F" first="Francoise" last="Gilard">Francoise Gilard</name><name sortKey="Lalande, Julie" sort="Lalande, Julie" uniqKey="Lalande J" first="Julie" last="Lalande">Julie Lalande</name><name sortKey="Martineau, Estelle" sort="Martineau, Estelle" uniqKey="Martineau E" first="Estelle" last="Martineau">Estelle Martineau</name><name sortKey="Martineau, Estelle" sort="Martineau, Estelle" uniqKey="Martineau E" first="Estelle" last="Martineau">Estelle Martineau</name><name sortKey="Mauve, Caroline" sort="Mauve, Caroline" uniqKey="Mauve C" first="Caroline" last="Mauve">Caroline Mauve</name></country><country name="Australie"><noRegion><name sortKey="Tea, Illa" sort="Tea, Illa" uniqKey="Tea I" first="Illa" last="Tea">Illa Tea</name></noRegion><name sortKey="Blackburn, Anneke C" sort="Blackburn, Anneke C" uniqKey="Blackburn A" first="Anneke C." last="Blackburn">Anneke C. Blackburn</name><name sortKey="Tcherkez, Guillaume" sort="Tcherkez, Guillaume" uniqKey="Tcherkez G" first="Guillaume" last="Tcherkez">Guillaume Tcherkez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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